Information Technology seminars
MURPA Seminar: Multi-Scale Modeling of the Heart
- Date and time:
- 04/09/2008, 9:30
- Location:
- Building: 26, Room: 135, Clayton Campus (via HD interactive video)
- Presenters:
- Prof. Andrew McCulloch
Dept. of BioEngineering, UCSD.
- Abstract:
- Following the successes of reductionist experimental biology, computational biology provides a tool for integrative analysis. Computation can be integrative in at least three ways. Bioinformatics has the goal of integrating biological information. Functional integration of molecular components into networks that model cellular subsystems is the goal of Systems Biology. Structural integration across physical scales of biological organization is the goal of multi-scale modeling. At UCSD we use these approaches to develop integrative multi-scale models of the electromechanics of the heart which we then apply to biomedical problems such as the mechanisms of sudden cardiac death and the use of cardiac resynchronization therapy for congestive heart failure.
- Speaker biographies:
- Andrew McCulloch is Professor and Chair of Bioengineering at the University of California San Diego, where he joined the faculty in 1987. He is member of the UCSD/Salk Institute for Molecular Medicine, the California Institute for Telecommunications and Information Technology, a Senior Fellow of the San Diego Supercomputer Center, and a member of the Whitaker Institute for Biomedical Engineering, and the UCSD Center for Research on Biological Systems.
Dr. McCulloch was educated at the University of Auckland, New Zealand in Engineering Science and Physiology receiving his Ph.D. in 1986. Dr. McCulloch was an NSF Presidential Young Investigator and is a Fellow of the American Institute for Medical and Biological Engineering. He has served on the Board of Directors of the Bio- Medical Engineering Society, and is currently Associate Editor of the Journal of Biomechanical Engineering and co-Editor-in-Chief of Drug Discovery Today: Disease Models. He is on the editorial boards of the American Journal of Physiology: Heart and Circulatory Physiology and Computer Methods in Biomechanics and Biomedical Engineering. In the past year he has given the Konrad Witzig Memorial Lecture and the Donald Wassenberg Memorial Lecture.
Dr. McCulloch?s lab uses experimental and computational models to investigate the relationships between the cellular and extracellular structure of cardiac muscle and the electrical and mechanical function of the whole heart during ventricular remodeling, and arrhythmia. Dr. McCulloch is a PI on the NCRR-supported National Biomedical Computation Resource, and has grants from the NHLBI, NSF and DOD on cardiac myocyte tissue engineering, the biomechanics of ventricular remodeling, signaling pathways in cardiac hypertrophy and failure, cardiac electromechanical interactions, and computational cardiac biology.
Dr. McCulloch co-founded Insilicomed in 2000.
- For more information, visit:
-
http://cmrg.ucsd.edu/AndrewMcCulloch
- Enquiries:
- Ronald Pose
- Research group website:
-
http://www.infotech.monash.edu.au/about/events/2008/murpa.html
